Smoking among pregnant women in Norway. Prevalence, self-report validity, and associations to SGA and “early programming” using family and sibling design

Background: Although a decline in smoking prevalence is seen in most developed countries, smoking during pregnancy remains an important public health concern, affecting both the mothers’ own health as well as that of her unborn child. Objectives: The objective was to study several aspects of smoking habits among pregnant women in Norway since 1999. Firstly, to assess changes and secular trends in smoking habits during pregnancy in the period 1999-2004. Secondly, to biochemically assess the validity of self-reported smoking habits in the Norwegian Mother and Child Cohort Study (MoBa). The third objective was to explore if women born with low birth weight more often end up as smokers as adults compared to women born with higher birth weight. The fourth aim was to assess the risk of small for gestational age (SGA) in 2nd pregnancy according to smoking habits in two successive pregnancies. Methods: Main data sources included The Medical Birth Registry of Norway with links to other registries (paper I: 1999-2004, paper III: 1967-2014 and paper IV: 1999-2014) and the MoBa (paper II: 2002-2003). Cross sectional files as well as generational and sibling files were used to pursue the objectives. Results: The overall daily smoking prevalence among Norwegian pregnant women decreased from 18% in 1999 to 11% in 2004 (Relative Risk (RR) 0.61, 95% Confidence Interval (CI) 0.58, 0.64)). The decline was observed in all subgroups. Maternal educational level was strongly associated with smoking at the end of pregnancy. More women quit smoking during pregnancy in the second half of the study period, compared to the first. Among a subsample of 2 997 women in MoBa an overall mean sensitivity of 81.9% (95% CI 77.3, 86.4) and specificity of 99.4% (95% CI 99.1, 99.7) was calculated for self-reported smoking habits with plasma cotinine concentrations as the gold standard. For the association between birth weight and later smoking habits we found that women born at term with low birth weight (